Why Biotech Investing Is Not for the Meek

By Lisa LaMotta Aug 12, 2010 12:50 pm

Biotech stocks are driven by catalysts even analysts have trouble predicting the outcomes of, so know your risks.



Biotech investing isn’t for the faint of heart and it’s certainly isn’t a long-term investment. Unlike its Big Pharma brethren, biotechs -- especially small and medium-sized biotechs -- are incredibly volatile. These stocks are driven by catalysts that even analysts have trouble predicting the outcomes of -- including FDA decisions, Advisory Committee meetings, and clinical trial data announcements. Even some of the drugs that seemed like a shoe-in often end up flopping unexpectedly. This wouldn’t have a huge effect on a Pfizer (PFE) or a Merck (MRK) -- companies that have market caps over $100 billion, but when a company’s market cap is under $100 million, its stock can shoot up or plummet in a matter of hours.

(See also, The Basics of Biotech Investing.)

For example, a small biopharmaceutical company called Amicus Therapeutics (FOLD) was having a good day on Thursday as its stock gained more than 15% before midday trading. While this only puts the stock at around $3.50, it could have made you money if you knew to expect it. Amicus’ good fortune came at the expense of its much larger competitor Genzyme (GENZ). The large biotech, which has been grabbing headlines recently due to Sanofi-Aventis (SNY) sniffing at its ankles, filed an SEC filing that stated it could take a year longer than expected to fix the manufacturing issues that have been affecting the supply of its two biggest drugs -- Fabrazyme for Fabry’s disease and Cerezyme for Gaucher’s disease. Amicus’ lead drug is in late-stage testing for the treatment of Fabry’s disease; it also has a candidate in the pipeline for Gaucher’s disease. Many other companies, including Pfizer and Shire Pharmaceuticals (SHPGY), have been trying to grab some of the market share for the two diseases now that Genzyme has dropped the ball on the only treatments available. Genzyme’s problems have created a rare opportunity for companies like Amicus to get a foothold in the market.

While these sometimes huge jumps in biotech stocks can be thrilling, it’s important for investors to remember that the downside of biotechs is that their stocks can fall just as quickly. Investors of Medivation (MDVN) learned this lesson all too quickly this past March. The stock had been flying high on “the next great Alzheimer’s drug,” until that drug, Dimebon, proved to be no better than a sugar pill when tested in late-stage clinical trials. The stock dropped more than 65% in a matter of an afternoon after the results were announced.

The immediate repercussions of a drop like this on an investor are obvious, but the ultimate consequences for the company can be even more damning. Many small- to mid-sized biotechs have yet to bring a product to market, and therefore have little-to-no product revenue. This means the failure of a lead drug candidate could force a company out of business.

One company that could be facing this situation is Vivus (VVUS). The biotech has been hot since its lead drug candidate proved to be the most effective of the weight-loss drugs currently trying to get through the FDA. Yet, Vivus stumbled when an FDA advisory committee voted against approval of Qnexa due to safety issues. If Vivus can’t find a way to bring Qnexa to market, the company may have to scramble to survive.

The main lessons of biotech investing are:

1. Do your homework; it’s important to know what drugs a company is depending on, what it has to fall back on, who its competitors are, and when its important catalysts will occur.

2. Act quickly; most of the rises and falls will happen within hours -- don’t wait around once the stock starts to fall or get out once the stock has climbed significantly.

3. Don’t be unwilling to take a risk; remember that these aren’t safe stocks, but the risks are worth the rewards.

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No positions in stocks mentioned.

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